Pom121 family
WebOct 2, 2024 · A loss-of-function genetic screen uncovered the nucleoporin POM121 as a key regulator of prostate cancer aggressiveness. POM121 was upregulated in advanced lethal prostate tumors, and its depletion disrupted nuclear import and suppressed prostate cancer cell growth in soft agar without altering nuclear pore complex integrity. WebJun 25, 2024 · Furthermore, we found that karyopherin-β1 (KPNB1), which belongs to the importin-β family, interacts with Pom121 and is involved in Pom121-mediated PIC nuclear import.
Pom121 family
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Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. See more The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous … See more • Bodoor K, Shaikh S, Enarson P, et al. (1999). "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–9. See more WebNX_Q96HA1 - POM121 - Nuclear envelope pore membrane protein POM 121 - Function. Essential component of the nuclear pore complex ... helps curators to infer annotations …
WebBelongs to the POM121 family. Domain. Contains F-X-F-G repeats. Cellular localization. Nucleus > nuclear pore complex. Nucleus membrane. ... Anti-POM121 antibody (ab137938) at 1/500 dilution + HUVEC cell lysate at 30 µg Predicted band size: 128 kDa. Protocols. Western blot protocols. WebNov 20, 2008 · Identification of several novel PAX5 partner genes, including POM121, ... The Janus kinase (JAK) family currently comprises four human members JAK1, JAK2, JAK3 and TYK2, ...
WebDr. Lars J. Brandén is an accomplished leader in biotech R&D with a strong background in design and implementation with innovative approaches to developing new technologies and new applications. Dr. Brandén has built and operated two cutting-edge High Throughput Cell Biology centers from the ground up and has developed over 180 high-content and low … WebDec 28, 2010 · Some nucleoporins are members of the Trp-Asp (WD) repeat family. ... Nup45, and Pom121) are also absent in yeast. Thus, it is possible that Nup358, Nup45, and Pom121 represent vertebrate-specific nucleoporins and that they may be involved in determining species-specific differences in NPC function and complexity. Figure 8.
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WebChappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS. chuck\u0027s paint and body shopWebbelongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and … chuck\u0027s paintingWebNuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in the … dessin de halloween facile a dessinerWebMyeloid zinc finger 1 (MZF1), also known as zinc finger protein 42, is a zinc finger transcription factor, belonging to the Krüppel-like family that has been implicated in several types of malignancies, including glioblastoma multiforme (GBM). MZF1 is reportedly an oncogenic gene that promotes tumor progression. Moreover, higher expression of … chuck\\u0027s parkingchuck\u0027s package store in morristown tnWebGene "Gene description" Evidence A1CF "APOBEC1 complementation factor" "Evidence at protein level" A4GALT "Alpha 1,4-galactosyltransferase (P blood group)" "Evidence at protein le chuck\u0027s parkingWebJun 11, 2024 · Furthermore, we found that karyopherin-β1 (KPNB1), which belongs to the importin-β family, interacts with Pom121 and is involved in Pom121-mediated PIC nuclear import. dessin de huggy wuggy a colorier