Diethoxycarbonyl-1 4-dihydrocollidine
Webcholestatic models are (1) common bile duct ligation and (2) dietary-based models such as 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet. Although both rodent models are well-established models to study PSC and PBC in vivo, DDC-fed mice model is especially useful in studies aiming at investigating ductular reaction WebFind diethoxycarbonyl-1,4-dihydrocollidine and related products for scientific research at MilliporeSigma
Diethoxycarbonyl-1 4-dihydrocollidine
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WebAug 11, 2024 · The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet model is a widely used animal model for cholestatic liver diseases [ 14, 15 ]. DDC is a porphyrinogenic agent and strong inducer of δ-aminolevulinate synthetase, the … WebSynonym (s): 3,5-Dicarbethoxy-1,4-dihydrocollidine, DDC. Empirical Formula (Hill Notation): C14H21NO4. CAS No.: 632-93-9. Molecular Weight: 267.32. EC No.: 211-188-0. Compare.
WebAbstract. Exposure of mice to a diet containing 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) induces porphyrin accumulation, cholestasis, immune response, and hepatobiliary …
WebThe hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit… Highly Cited 1973 Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice. F. De Matteis, G. Abbritti, A. Gibbs WebApr 24, 2024 · The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet model is a widely used animal model for cholestatic liver diseases [14, 15]. DDC is a porphyrinogenic agent and strong inducer of...
Web【Animal Modeling】-Therapeutic effect of rapamycin on DDC-induced primary sclerosing cholangitis in mice. To investigate the therapeutic effect of rapamycin on 3,5-diethoxycarbonyl 1,4-dihydrocollidine (DDC)-induced mouse primary sclerosing cholangitis (PSC), and to explore its potential mechanism...
WebIn vivo, cholestatic mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) were treated with apigenin. Apigenin potently blocked DDC-induced gallbladder atrophy … image ice pickWebreceptor 2; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; AST, aspartate aminotransferase; ALT, alanine aminotransferase. ***P<0.005 com-pared with the control group. #P<0.05 compared with the DDC model group. A C B D 600 400 200 0 25 20 15 10 5 0 80 60 40 20 0 40 30 20 10 0 ALT activity (U/L) image i can only imagineWebof 3,5-dieythioxycarbonyl-1,4-dihydrocollidine (C 14 H 21 NO 4) (CAS Number 632-93-9). Standard diet is Teklad Global diet 2014 containing wheat midds, wheat, corn and corn … image ichigo bleachWebXenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying mechanisms are largely unknown. Therefore, we aimed to characterize the cause and consequences of hepatobiliary injury and biliary fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice as a novel model of xenobiotic-induced cholangiopathy. image i am not an early bird or a night owlWebJun 14, 2013 · 3,5-diethoxycarbonyl-1,4-dihydrocollidine Apoptosis Regulatory Proteins Forkhead Box Protein O3 Forkhead Transcription Factors FoxO3 protein, mouse Immediate-Early Proteins Pyridines RNA, Small Interfering Protein Serine-Threonine Kinases serum-glucocorticoid regulated kinase Paraquat Grant support DK56339/DK/NIDDK NIH … image id codes for club roblox cuteWebIn vivo, cholestatic mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) were treated with apigenin. Apigenin potently blocked DDC-induced gallbladder atrophy and associated liver injury, fibrosis and collagen accumulation. image ibis rougeWebMar 4, 2024 · We performed experiments with C57BL/6 J mice treated with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and melatonin to verify the role of melatonin in the mouse model of cholestasis. Primary mouse hepatocytes were used for in vitro studies to study the mechanisms of action of melatonin in cholestasis. The levels of … image i and the father are one