Cytosolic dna-sensing pathway是什么

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August undefined, 2024

WebApr 30, 2024 · Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special ... Metrics - Cytosolic DNA sensing by cGAS: regulation, function, and human ... - Nature Full Size Table - Cytosolic DNA sensing by cGAS: regulation, function, and human … Full Size Image - Cytosolic DNA sensing by cGAS: regulation, function, and human … Signal Transduction and Targeted Therapy is an online-only, open access journal … WebDec 30, 2024 · Recent evidence has indicated that cytosolic DNA and abnormal activation of the cytosolic DNA sensing adaptor STING (stimulator of interferon genes) play a critical role in vascular …

Recognition of Cytosolic DNA Review InvivoGen

WebMany studies have demonstrated the involvement of DNA-sensing pathways in antitumor responses as well as tumor development. Cancer cells often contain cytosolic DNA, which may not be present under physiological conditions. ... Jiang N, May H II, Li T, et al. Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs … WebDec 20, 2012 · Our results not only demonstrate that cGAS is a cytosolic DNA sensor that triggers the type I interferon pathway, but also reveal a mechanism of immune signaling … nothilfe dos

Detection and quantification of cytosolic DNA - PubMed

WebBiological pathway information for Cytosolic DNA-sensing pathway from WikiPathways. WebApr 30, 2024 · The cGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA. DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern when leaked into the cytoplasm from damaged mitochondria or … WebMay 23, 2013 · LRRFIP1 senses cytosolic DNA and phosphorylates β-catenin, which translocates to the nucleus and promotes IFN-β transcription. The DNA-PKc-Ku70-Ku80 … how to set up apple icloud account

The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer

Cytosolic DNA sensing by cGAS: regulation, function, and …

WebApr 13, 2024 · The authors next sought to explore the impact of compromising this DNA sensing pathway by eliminating the intermediate kinase ZAK. T cell-specific deletion of Zak did not affect T cell development or maturation. Nuclear DNA damage and cytosolic DNA accumulation also occurred normally when Zak-deficient CD4 + T cells age. Upstream … WebCytosolic DNA-mediated production of type I IFNs (mainly IFN-β) requires the transcription factor IFN ... 2012. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing … nothilfe diakonieWebDec 30, 2024 · Cytosolic DNA and abnormal activation of cytosolic DNA sensing signaling play critical roles in sporadic aortic destruction, dilatation, dissection, and rupture. Targeting cytosolic DNA sensing adaptor … nothilfe frankfurt

"WebDec 20, 2012 · To determine whether cGAS is important in the DNA sensing pathway in human cells, we established a THP1 cell line stably expressing a shRNA targeting h-cGAS (fig. S4D). The knockdown of h-cGAS strongly inhibited IFN-β induction by HT-DNA transfection or infection by vaccinia virus, another DNA virus, but not by Sendai virus (fig. … " - Cytosolic dna-sensing pathway是什么

Cytosolic dna-sensing pathway是什么

The cGAS-STING Pathway: Novel Perspectives in Liver Diseases

WebApr 30, 2024 · DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern … WebJun 20, 2013 · Our results explain the broad DNA sensing specificity of cGAS, show how cGAS catalyses dinucleotide formation and indicate activation by a DNA-induced …

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WebNov 30, 2024 · Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cytosolic DNA sensing pathways are … WebJul 13, 2024 · Once activated by cytosolic DNA signalling, ... Green R, Gale M, Jr., James RC, et al. Human DNA-PK activates a STING-independent DNA sensing pathway. Sci Immunol. 2024;5:eaba4219.

WebJan 1, 2014 · The NLR pathway has also been shown to be important in sensing cytosolic DNA but triggers inflammasome-dependent innate immune signaling. This involves … WebUpon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.

WebJan 1, 2024 · Importantly, we found that the pharmacologic inhibition of STING activation can reduce AAD development in mice. Our study findings suggest that the cytosolic DNA–mediated activation of cytosolic DNA sensing adaptor STING plays a critical role in aortic degeneration and is a potential therapeutic target for treating sporadic AAD. WebApr 30, 2024 · Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special ...

WebCytosolic DNA sensing is emerging to be a critical component of the antitumor immune response by jumpstarting innate immune responses subsequent to the stimulation of the cGAS and STING pathway. Investigating the accumulation of DNA species in the cytosol is therefore an essential readout for promising anticancer strategies.

WebActivation of cytosolic DNA sensing pathways impacts on autophagy and tumor antigens (Ags) cross-presentation in DCs. Type-I IFNs production by DCs actually represents the … nothilfe fuldaWebMay 5, 2013 · Cytosolic signaling pathways activated by DNA have been uncovered, new DNA receptors proposed, and we now know that innate DNA recognition is closely … nothilfe e.vWebSep 10, 2024 · Cytosolic DNA Sensing in Organismal Tumor Control. Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is … how to set up apple id passwordWebThe Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer. The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved mechanism to initiate … how to set up apple iphone accountWebThe recognition of cytosolic DNA is more complicated than first anticipated. Several sensors have been identified that trigger different signaling pathways in a cell type-specific manner. Still, the general … how to set up apple iphone 11WebhcGAS只识别长片段DNA的分子机理。 hcGAS两个关键位点的突变刚好位于一个特别的DNA结合区域，比对mcGAS模型可发现，该区域对于cGAS识别短片段DNA是必需的，但对长片段DNA识别则没有什么作用——这解释 … how to set up apple id on iphone 13WebJul 29, 2024 · Cytosolic DNA sensing by the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is implicated in a variety of biological processes. how to set up apple id on iphone 12