WebRelentless, repetitive itching and scratching is a debilitating feature of many chronic inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch-scratch cycle has historically lacked in-depth mechanistic understanding. However, recent advances at the interface of … WebFeb 24, 2024 · Cytokine Signaling Comes to the Fore in Inflammatory Itch Disease. New evidence shows that the cytokine oncostatin M (OSM) potentiates itch signaling in neurons and is a key mediator of inflammatory itch disease in humans. Blocking OSM signaling could be an exciting new treatment for chronic itch. by Fred Schwaller on 24 Feb 2024.
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WebAbstract. Itch treatment is a major challenge in the dermatologist's practice. We encounter patients suffering from pruritus on a regular basis, and often lack diverse treatment options to adequately respond to the patients' needs. In the last 20 years, novel pathways have been investigated that were beyond the scope of histamine. WebThe development of insights into the role of cytokine modulation of pain has been the prototypical story of translational research from mouse to man. Pain has been understood in the context of inflammation associated with … reach licence
Emerging Treatments and Novel Pathways in Pruritus - PubMed
WebOct 1, 2024 · New studies reveal how cytokines can directly modulate sensory neurons to influence atopic itch. Disrupting neuronal cytokine responses may explain successes in new AD therapies. Atopic dermatitis (AD) is an inflammatory skin disease characterized by two primary features: relapsing skin lesions and chronic itch. WebAug 29, 2024 · Itching is a common symptom of diabetes, a chronic condition in which your blood sugar is too high. 1 Itching from diabetes can be caused by dry skin, poor circulation, or certain infections. It can also be annoying enough to interfere with your daily life. WebJul 30, 2024 · Cytokine is a small protein made and secreted by cells that sends a signal to another cell to respond in a certain way; Histamine is a chemical involved in activating immune responses and activating nerves in the skin to send signals to the spinal cord and brain to signal itchiness. how to stain brass black