Adipocyte apoptosis
WebJul 5, 2024 · In BAT, apoptosis is a continuing process and chronic inactivation (for example, thermoneutrality or denervation) results in reduced activity and abundance of … WebMay 29, 2024 · In obese C57BL/6 mice, oral administration of T-AG17 (0.175 mg/kg for 2 weeks) lead to decreased fat accumulation and WAT hypertrophy. Further, T-AG17 induced adipocyte apoptosis by activating caspase-3. In the hepatocytes of obese mice, T-AG17 promoted an increase in the size of lipid inclusions, which was accompanied by glycogen …
Adipocyte apoptosis
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WebNational Center for Biotechnology Information WebJan 6, 2012 · Apoptosis is a normal phenomenon of cell death for the purpose of maintaining homeostasis. Induction of apoptosis is a reasonable way to remove adipocytes in obese patients. It is reported that several adipokines and natural products play roles in induction of adipocyte apoptosis.
WebNov 1, 2001 · Adipocyte apoptosis is an important regulator of adipocyte number in fat depots. We have previously shown that an inhibition of protein synthesis sensitizes human adipocytes for apoptosis. In vivo ... WebSep 24, 2024 · Adipocytes were cultured in vitro, and a diet-induced obesity (diet-induced obesity) rat model was established to explore the effects of apelin-13 on Bcl-2 and caspase-3 factors in vivo and in vitro and its influence on the apoptosis of adipocytes. The specific report is as follows. 2. Materials and Methods 2.1. Cell Culture
WebOct 27, 1997 · It is shown that human adipocytes undergo apoptosis following growth factor deprivation or mild heat injury in vitro, thus demonstrating a cellular mechanism by which normal adipocyte loss could occur in vivo. 96 Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. WebApoptosis or programmed cell death is a central mechanism for maintaining homeostasis. This natural process of cell removal enables the body to rid itself of selected cells safely and effectively. 1 The potential benefits of induced apoptosis, specifically to the abdominal region, extends beyond aesthetics as it may help reduce metabolic complications in …
WebApoptotic pathways in adipose tissue. To treat the ever growing number of obese patients, reduction of adipocyte number by apoptosis may complement other therapeutic options. On the other hand in free fat grafts, apoptosis along with necrosis is responsible for long …
WebMar 2, 2024 · TNFα-induced apoptosis and gene expression are critical in human adipocyte apoptosis. An in vitro study demonstrated 3T3-L1 adipocyte apoptosis induced by TNF-α was essentially regulated via controlling NF-κB activation, by targeting the TANK gene 18. Adiponectin is an important adipocyte-secreted adipokine. aspen talksWebMay 19, 2016 · TAK1 deficiency in adipocytes leads to increased rate of apoptosis. To generate inducible white adipocyte–specific TAK1-deficient mice, we crossed the AdipoqCreER T2 mouse line with mice carrying a floxed allele of TAK1 ().Adipocyte-specific, tamoxifen-inducible TAK1-deficient mice (AdipoqCreER T2+/–;TAK1 fl/fl, … aspen tailorWebJan 24, 2012 · Adipocyte apoptosis is an important mechanism for regulating adipocyte cell number, and its regulation is important in obesity-combating strategies . SBM-induced apoptosis could be implicated in SBM's ability to block Akt signaling (Figure 5A) and induce TNFα expression (Figure 4C). aspen summit 631aspen tan stainWebJun 1, 2016 · TNF-α is a pro-inflammatory cytokine that is increased in obese WAT and induces adipocyte apoptosis in more than 50% of the cells after 24 h of incubation (23, 29). We note that the mechanism of adipocyte death in vivo is controversial and other forms of cell death, such as pyroptosis, may play a role in addition to apoptosis (12, 30, 31 ... aspen taillight lensWebApr 11, 2024 · Isolation and identification of human ADSCs. A The isolated ADSCs exhibited typical fibroblast-like morphology. Bar: 100 μm. B Induction of ADSCs into adipocytes, osteoblast, and chondrocytes with adipogenic, osteogenic and chondrogenic medium, respectively. Bar:100 μm. C ADSCs showed strong positive (more than 95%) expression … lakin kemenkeuWebOct 12, 2024 · Adipose tissue plays a crucial role in the regulation of metabolic homeostasis through cross talk with other metabolic tissues. Adipose tissue is expanded by two processes, formation of new adipocytes (hyperplasia) and enlargement of existing adipocytes (hypertrophy) ( 1 ). aspen tankstelle